New Stroke Technology: Stent and Pressure Activated Nanoparticles to Bust Clots

Stroke-Figure605Some ischemic strokes are now successfully treated using intravascular clot retrieval devices, but in many instances this option is not advised. Moreover, the retriever can dislodge bits of the clot that end up embolizing deeper into the brain. Clot busting drugs, on the other hand, can’t get into a complete occlusion since there’s no blood flow. A team from Harvard’s Wyss Institute and University of Massachusetts’ New England Center for Stroke Research have developed a new approach that combines a device that creates a tunnel through the clot with pressure activated nanoparticles that release clot busting drugs when passing through the narrow channel.

The particles mimic how platelets stick to vessel walls where blood undergoes high pressures. Tissue plasminogen activator (tPA) coated over the nanoparticles release when the particles stick to the clot, dissolving it quickly at the point of occlusion. Any dislodged bits of the clot should also get a nanoparticle or two stuck to them. So as they travel down the vasculature they continue to be dissolved to prevent further harm. The stent that’s driven through the initial clot remains in place during the introduction of the nanoparticles and is retrieved at the end of the procedure.


About Peter Coffaro 1436 Articles
A growth-driven and strategic executive, Peter Coffaro commands more than 20 years of progressive management success within the medical device industry. As a District Sales Manager for Stryker Orthopaedics, Peter was responsible for managing and directing a regional sales force to achieve sales and profit goals within the Rocky Mountain region. Previously, he was the Director of Sales & Marketing for Amp Orthopedics. In this role, Peter was responsible for planning, developing, and leading all sales and marketing initiatives. Peter is a former orthopedic distributor in the Pacific Northwest. He has also worked with DePuy Orthopaedics as well as Zimmer, and held positions in sales, sales training, and sales management. Peter has an extensive background in organizational development, business development, sales management, negotiating and P&L management. Peter holds a B.S. degree in Biology from Northern Illinois University.

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