Nontoxic, biodegradable orthopedic implant could provide superior support to damaged bones, be safely absorbed by the body

Purdue University researchers are developing a nontoxic, biodegradable orthopedic implant that could be safely absorbed by the body after providing adequate support to damaged bones.

The development of the technology originated in the lab of Lia Stanciu, a professor of materials engineering at Purdue in 2009. The technology could eliminate the need for a second surgery to remove conventional hardware.

“Currently, most implants use stainless steel and titanium alloys for strength. This can cause long-term change in the mechanics of the specific region and eventual long-term deterioration,” Stanciu said. “Additionally medical operations that require an orthopedic implant must be followed-up with a second surgery to remove the implant or the accompanying hardware of the implant resulting in higher medical costs and an increased risk of complications.”

Co-inventors of the technology are Stanciu; Eric Nauman, a professor in Purdue’s College of Engineering and director of the College of Engineering Honors Programs; Michael J Heiden, a PhD candidate; and Mahdi Dehestani, a graduate research assistant, both in Purdue’s School of Materials Engineering.

Nauman said the resorbable metal technology provides superior properties compared to conventional metals.

“The implant has high porosity, which is empty space in the material, in which optimal vascular invasion can occur. This provides a way for cells to optimally absorb the material,” he said. “Our technology is able to provide short-term fixation but eliminate the need for long-term hardware such as titanium or stainless steel that may require second surgeries to be retrieved,”

By Purdue University | Research Foundation

Image Credit: Marine Traverson and Gert Breur, Purdue College of Veterinary Medicine

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