Genetic Basis for Joint Replacement Failure

Scientists from ExplantLab have identified a genotype that is associated with joint replacement failure in some patients. Based on these findings, the scientists developed a machine-learning algorithm called Orthotype, which uses a patient’s genotype and other factors to accurately predict the outcome of joint replacement surgery.

More than five million joint replacements are performed globally each year. Although most patients are satisfied with the results of their surgery, a significant number of joint replacements fail early, following adverse immune responses.

One of the most popular implant materials used in joint replacements is cobalt chrome (CoCr). When small particles from CoCr joints are released into the blood, it can lead to an immune response that results in pain and joint failure in some patients.

“Essentially, the immune system attacks the implant in a process similar to how a patient rejects an organ transplant,” explained David Langton, PhD, director of ExplantLab. “How quickly this happens is variable and unpredictable, but it appears to be dependent on the type of material, the amount of wear debris released, and other patient-specific factors.”

One of those patient-specific factors is their genes. The HLA genes play a central role in immune function, and Langton and his colleagues determined that patients with certain HLA genotypes are likely to develop responses to CoCr-containing implants. Their results were published in Communications Medicine.

By Genetic Engineering News

Image Credit: Getty Images


About Peter Coffaro 506 Articles
Peter Coffaro is a growth-driven and strategic executive with over 25 years of progressive management success in the medical device industry. With a proven track record and recognized expertise, Peter has established himself as one of the top influencers in medical sales, as acknowledged by prestigious publications such as the World Journal of Orthopedics, Exponential Healthtech, and Throughout his career, Peter has accumulated 10 years of combined sales management experience, excelling in various roles including Director, General Manager, Distributor, and Vice President. He has worked for industry-leading orthopedic companies such as Zimmer, DePuy, and Stryker, solidifying his deep knowledge and network within the field. Peter’s passion for innovation and emerging technologies led him to found OrthoFeed, an award-winning blog covering digital orthopedic news and emerging medical technologies. Through this platform, he stays at the forefront of the industry and contributes to the dissemination of valuable insights. Peter is a three-time Hall of Fame award winner at Johnson and Johnson, demonstrating his exceptional contributions and impact on the organization. His expertise extends to areas such as organizational development, business development, sales management, digital marketing, and professional education. Peter earned a B.S. degree in Biology and Chemistry from Northern Illinois University, further complementing his comprehensive understanding of the medical field. With his wealth of experience, strategic mindset, and dedication to advancing healthcare, Peter Coffaro is a valuable asset and leader in the medical device industry.


  1. Very Informative… This Blog Covered all most everything related to joint Replacement and the Remedies to cure It. Detailed very Professionally. Must-Read by People having queries regarding this

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